Mouse Spef2 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Spef2
Locus ID	320277
Kit Components	GA216464G1, Spef2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA216464G2, Spef2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA216464G3, Spef2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001305042, NM_001305044, NM_177123
Synonyms	C230086A09Rik
Summary	Required for correct axoneme development in spermatozoa (PubMed:21715716, PubMed:28619825). Important for normal development of the manchette and sperm head morphology (PubMed:28619825). Essential for male fertility (PubMed:21715716, PubMed:28619825). Plays a role in localization of the intraflagellar transport protein IFT20 to the manchette, suggesting function as an adapter for dynein-mediated protein transport during spermatogenesis. Also plays a role in bone growth where it seems to be required for normal osteoblast differentiation (PubMed:28619825).[UniProtKB/Swiss-Prot Function]

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