Mouse Cep295 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Cep295
Locus ID	319675
Kit Components	GA216330G1, Cep295 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA216330G2, Cep295 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA216330G3, Cep295 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_176976
Synonyms	5830418K08Rik; 5832426L23Rik; Gm1131; Kiaa1731
Summary	Centriole-enriched microtubule-binding protein involved in centriole biogenesis. Essential for the generation of the distal portion of new-born centrioles in a CENPJ- and CEP120-mediated elongation dependent manner during the cell cycle S/G2 phase after formation of the initiating cartwheel structure. Required for the recruitment of centriolar proteins, such as POC1B, POC5 and CEP135, into the distal portion of centrioles. Also required for centriole-to-centrosome conversion during mitotic progression, but is dispensable for cartwheel removal or centriole disengagement. Binds to and stabilizes centriolar microtubule.[UniProtKB/Swiss-Prot Function]

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