Mouse Mbtps2 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Mbtps2
Locus ID	270669
Kit Components	GA216094G1, Mbtps2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA216094G2, Mbtps2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA216094G3, Mbtps2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_172307, NM_178266
Synonyms	9630032G22Rik; AI662535
Summary	Involved in regulated intramembrane proteolysis (RIP) that is the cleavage of membrane-spanning regulatory proteins by proteases within the plane of the membrane. It cleaves sterol-regulatory element-binding proteins (SREBPs) within the first transmembrane segment, thereby releasing the N-terminal segment with a portion of the transmembrane segment attached. Mature N-terminal fragments shuttle to the nucleus and activate gene transcription. Involved in RIP-mediated regulation of bone formation.[UniProtKB/Swiss-Prot Function]

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