Mouse Clspn activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Clspn
Locus ID	269582
Kit Components	GA216017G1, Clspn gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA216017G2, Clspn gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA216017G3, Clspn gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_175554
Synonyms	B130025E01; C85083; E130314M08Rik
Summary	Required for checkpoint mediated cell cycle arrest in response to inhibition of DNA replication or to DNA damage induced by both ionizing and UV irradiation. Adapter protein which binds to BRCA1 and the checkpoint kinase CHEK1 and facilitates the ATR-dependent phosphorylation of both proteins. Can also bind specifically to branched DNA structures and may associate with S-phase chromatin following formation of the pre-replication complex (pre-RC). This may indicate a role for this protein as a sensor which monitors the integrity of DNA replication forks (By similarity).[UniProtKB/Swiss-Prot Function]

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