Mouse Vps39 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Vps39
Locus ID	269338
Kit Components	GA216000G1, Vps39 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA216000G2, Vps39 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA216000G3, Vps39 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_147153, NM_178851, NR_027618, NM_001363053, NM_001363054
Synonyms	A230065P22Rik; AW743070; mVam6; Vam6; Vam6P
Summary	May play a role in clustering and fusion of late endosomes and lysosomes (By similarity). Regulator of TGF-beta/activin signaling, inhibiting SMAD3- and activating SMAD2-dependent transcription. Acts by interfering with SMAD3/SMAD4 complex formation, this would lead to inhibition of SMAD3-dependent transcription and relieve SMAD3 inhibition of SMAD2-dependent promoters, thus increasing SMAD2-dependent transcription (By similarity).[UniProtKB/Swiss-Prot Function]

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