Mouse Sh3rf2 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Sh3rf2
Locus ID	269016
Kit Components	GA215976G1, Sh3rf2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA215976G2, Sh3rf2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA215976G3, Sh3rf2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001146299, NM_172966
Synonyms	2310046K19; 9130023G24Rik; AI452083; Ppp1r39; RNF158
Summary	Has E3 ubiquitin-protein ligase activity. Acts as an anti-apoptotic regulator of the JNK pathway by ubiquitinating and promoting the degradation of SH3RF1, a scaffold protein that is required for pro-apoptotic JNK activation. Facilitates TNF-alpha-mediated recruitment of adapter proteins TRADD and RIPK1 to TNFRSF1A and regulates PAK4 protein stability via inhibition of its ubiquitin-mediated proteasomal degradation. Inhibits PPP1CA phosphatase activity (By similarity).[UniProtKB/Swiss-Prot Function]

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