Mouse Zswim8 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Zswim8
Locus ID	268721
Kit Components	GA215945G1, Zswim8 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA215945G2, Zswim8 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA215945G3, Zswim8 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001252081, NM_001252082, NM_027996, NM_175544
Synonyms	2310021P13Rik; 4832404P21Rik; Kiaa0913; mKIAA0913
Summary	Substrate recognition component of a SCF-like E3 ubiquitin-protein ligase complex that promotes target-directed microRNA degradation (TDMD), a process that mediates degradation of microRNAs (miRNAs) (PubMed:33184237). The SCF-like E3 ubiquitin-protein ligase complex acts by catalyzing ubiquitination and subsequent degradation of AGO proteins (AGO1, AGO2, AGO3 and/or AGO4), thereby exposing miRNAs for degradation (By similarity). Specifically recognizes and binds AGO proteins when they are engaged with a TDMD target (By similarity). May also acts as a regulator of axon guidance: specifically recognizes misfolded ROBO3 and promotes its ubiquitination and subsequent degradation (By similarity).[UniProtKB/Swiss-Prot Function]

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