Mouse Shprh activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Shprh
Locus ID	268281
Kit Components	GA215905G1, Shprh gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA215905G2, Shprh gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA215905G3, Shprh gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001077707, NM_001284354, NM_172937
Synonyms	2610103K11Rik; AA450458; AU024614; BC006883; D230017O13Rik; E130018M05
Summary	E3 ubiquitin-protein ligase involved in DNA repair. Upon genotoxic stress, accepts ubiquitin from the UBE2N-UBE2V2 E2 complex and transfers it to 'Lys-164' of PCNA which had been monoubiquitinated by UBE2A/B-RAD18, promoting the formation of non-canonical poly-ubiquitin chains linked through 'Lys-63'.[UniProtKB/Swiss-Prot Function]

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