Mouse Prrt1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Prrt1
Locus ID	260297
Kit Components	GA215886G1, Prrt1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA215886G2, Prrt1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA215886G3, Prrt1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_030890, NM_001368728, NM_001368729, NM_001368730
Synonyms	Bat-4; Bat4; D17H6S54E; DSPD1; G5b; NG5; ORF31
Summary	Required to maintain a pool of extrasynaptic AMPA-regulated glutamate receptors (AMPAR) which is necessary for synapse development and function (PubMed:29490264). Regulates AMPAR function and synaptic transmission during development but is dispensable at mature hippocampal synapses (PubMed:29490264, PubMed:31216424). Plays a role in regulating basal phosphorylation levels of glutamate receptor GRIA1 and promotes GRIA1 and GRIA2 cell surface expression (PubMed:31216424).[UniProtKB/Swiss-Prot Function]

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