Mouse Spag4 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Spag4
Locus ID	245865
Kit Components	GA215306G1, Spag4 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA215306G2, Spag4 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA215306G3, Spag4 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_139151
Synonyms	1700041K21Rik; mKIAA4118; MNCb-0953; Sun4
Summary	Involved in spermatogenesis. Required for sperm head formation but not required to establish and maintain general polarity of the sperm head. Required for anchoring and organization of the manchette. Required for targeting of SUN3 and probably SYNE1 through a probable SUN1:SYNE3 LINC complex to the nuclear envelope and involved in accurate posterior sperm head localization of the complex. May anchor SUN3 the nuclear envelope. Involved in maintenance of the nuclear envelope integrity. May assist the organization and assembly of outer dense fibers (ODFs), a specific structure of the sperm tail.[UniProtKB/Swiss-Prot Function]

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