Mouse Rragb activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Rragb
Locus ID	245670
Kit Components	GA215295G1, Rragb gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA215295G2, Rragb gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA215295G3, Rragb gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001004154
Synonyms	MGC69750; MGC95567
Summary	Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade. Forms heterodimeric Rag complexes with RRAGC or RRAGD and cycles between an inactive GDP-bound and an active GTP-bound form. In its active form participates in the relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. Involved in the RCC1/Ran-GTPase pathway.[UniProtKB/Swiss-Prot Function]

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