Mouse Prag1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Prag1
Locus ID	244418
Kit Components	GA215196G1, Prag1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA215196G2, Prag1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA215196G3, Prag1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_172911
Synonyms	9830148H23; D8Ertd82e; mFLJ00269; NACK; Sgk223
Summary	Catalytically inactive protein kinase that acts as a scaffold protein (By similarity). Functions as an effector of the small GTPase RND2, which stimulates RhoA activity and inhibits NGF-induced neurite outgrowth (By similarity). Promotes Src family kinase (SFK) signaling by regulating the subcellular localization of CSK, a negative regulator of these kinases, leading to the regulation of cell morphology and motility by a CSK-dependent mechanism (By similarity). Acts as a critical coactivator of Notch signaling (PubMed:25038227).[UniProtKB/Swiss-Prot Function]

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