Mouse Erlin2 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Erlin2
Locus ID	244373
Kit Components	GA215194G1, Erlin2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA215194G2, Erlin2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA215194G3, Erlin2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_153592, NM_001364476, NM_001364477
Synonyms	BC036333; C87251; Spfh2
Summary	Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs) such as ITPR1. Promotes sterol-accelerated ERAD of HMGCR probably implicating an AMFR/gp78-containing ubiquitin ligase complex. Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. May promote ER retention of the SCAP-SREBF complex (By similarity).[UniProtKB/Swiss-Prot Function]

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