Mouse Mrgprb2 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Mrgprb2
Locus ID	243979
Kit Components	GA215172G1, Mrgprb2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA215172G2, Mrgprb2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA215172G3, Mrgprb2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_175531
Synonyms	4833406I20Rik; Mgrg14
Summary	Mast cell-specific receptor for basic secretagogues, i.e. cationic amphiphilic drugs, as well as endo- or exogenous peptides, consisting of a basic head group and a hydrophobic core. Recognizes and binds small molecules containing a cyclized tetrahydroisoquinoline (THIQ), such as non-steroidal neuromuscular blocking drugs (NMBDs), including tubocurarine and atracurium. In response to these compounds, mediates pseudo-allergic reactions characterized by histamine release, inflammation and airway contraction (PubMed:25517090).[UniProtKB/Swiss-Prot Function]

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