Mouse Nfkbid activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Nfkbid
Locus ID	243910
Kit Components	GA215162G1, Nfkbid gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA215162G2, Nfkbid gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA215162G3, Nfkbid gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_172142, NM_001360906, NM_001360907
Synonyms	IkappaBNS
Summary	Regulates the expression of IL-2, IL-6, and other cytokines through regulation on NF-kappa-B activity. Functions in the regulation of inflammatory responses (PubMed:11931770, PubMed:15749903, PubMed:16410444, PubMed:16413922, PubMed:17641034). Involved in the induction of T helper 17 cells (Th17) differentiation upon recognition of antigen by T cell antigen receptor (TCR) (PubMed:25282160). According to PubMed:11931770, it may also regulate TCR-induced negative selection of thymocytes (PubMed:11931770).[UniProtKB/Swiss-Prot Function]

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