Mouse Kbtbd8 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Kbtbd8
Locus ID	243574
Kit Components	GA215137G1, Kbtbd8 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA215137G2, Kbtbd8 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA215137G3, Kbtbd8 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001008785, NM_001102670
Synonyms	AU040152; mKIAA1842; SSEC-51; SSEC51; Takrp
Summary	Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(KBTBD8) complex acts by mediating monoubiquitination of NOLC1 and TCOF1: monoubiquitination promotes the formation of a NOLC1-TCOF1 complex that acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification.[UniProtKB/Swiss-Prot Function]

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