Mouse Fbxl5 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Fbxl5
Locus ID	242960
Kit Components	GA215095G1, Fbxl5 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA215095G2, Fbxl5 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA215095G3, Fbxl5 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001159963, NM_178729
Synonyms	Fbl4; Fir4
Summary	Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in iron homeostasis by promoting the ubiquitination and subsequent degradation of IREB2/IRP2. Upon high iron and oxygen level, it specifically recognizes and binds IREB2/IRP2, promoting its ubiquitination and degradation by the proteasome. Promotes ubiquitination and subsequent degradation of DCTN1/p150-glued (By similarity).[UniProtKB/Swiss-Prot Function]

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