Mouse Dact2 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Dact2
Locus ID	240025
Kit Components	GA214888G1, Dact2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA214888G2, Dact2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA214888G3, Dact2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_172826
Synonyms	2900084M21Rik; A630024E20; dapper2; Dpr2; Frd2
Summary	Involved in regulation of intracellular signaling pathways during development. Negatively regulates the Nodal signaling pathway, possibly by promoting the lysosomal degradation of Nodal receptors, such as TGFBR1. May be involved in control of the morphogenetic behavior of kidney ureteric bud cells by keeping cells epithelial and restraining their mesenchymal character. May play an inhibitory role in the re-epithelialization of skin wounds by attenuating TGF-beta signaling.[UniProtKB/Swiss-Prot Function]

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