Mouse Arhgap22 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Arhgap22
Locus ID	239027
Kit Components	GA214823G1, Arhgap22 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA214823G2, Arhgap22 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA214823G3, Arhgap22 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_153800
Synonyms	B230341L19Rik; p68RacGAP; RHOGAP2
Summary	Rho GTPase-activating protein involved in the signal transduction pathway that regulates endothelial cell capillary tube formation during angiogenesis. Acts as a GTPase activator for the RAC1 by converting it to an inactive GDP-bound state. Inhibits RAC1-dependent lamellipodia formation. May also play a role in transcription regulation via its interaction with VEZF1, by regulating activity of the endothelin-1 (EDN1) promoter.[UniProtKB/Swiss-Prot Function]

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