Mouse Gnl3l activation kit by CRISPRa
CAT#: GA214705
Gnl3l CRISPRa kit - CRISPR gene activation of mouse guanine nucleotide binding protein-like 3 (nucleolar)-like
CNY 12255.00
Specifications
Product Data | |
Format | 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug) |
Symbol | Gnl3l |
Locus ID | 237107 |
Kit Components | GA214705G1, Gnl3l gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA214705G2, Gnl3l gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA214705G3, Gnl3l gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077 |
Reference Data | |
RefSeq | NM_001168600, NM_198110 |
Synonyms | BC020354 |
Summary | Stabilizes TERF1 telomeric association by preventing TERF1 recruitment by PML. Stabilizes TERF1 protein by preventing its ubiquitination and hence proteasomal degradation. Does so by interfering with TERF1-binding to FBXO4 E3 ubiquitin-protein ligase. Required for cell proliferation. By stabilizing TRF1 protein during mitosis, promotes metaphase-to-anaphase transition. Stabilizes MDM2 protein by preventing its ubiquitination, and hence proteasomal degradation. By acting on MDM2, may affect TP53 activity. Required for normal processing of ribosomal pre-rRNA. Binds GTP (By similarity).[UniProtKB/Swiss-Prot Function] |
Documents
Resources
基因表达相关资源 |
Other Versions
SKU | Description | Size | Price |
---|---|---|---|
KN507096 | Gnl3l - KN2.0, Mouse gene knockout kit via CRISPR, non-homology mediated. |
CNY 8680.00 |