Mouse Ercc6l activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Ercc6l
Locus ID	236930
Kit Components	GA214696G1, Ercc6l gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA214696G2, Ercc6l gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA214696G3, Ercc6l gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_146235
Synonyms	BC004701; D330021P09Rik
Summary	DNA helicase that acts as an essential component of the spindle assembly checkpoint. Contributes to the mitotic checkpoint by recruiting MAD2 to kinetochores and monitoring tension on centromeric chromatin. Acts as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase. Functions as ATP-dependent DNA translocase. Can promote Holliday junction branch migration (in vitro).[UniProtKB/Swiss-Prot Function]

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