Mouse Pdk3 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Pdk3
Locus ID	236900
Kit Components	GA214692G1, Pdk3 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA214692G2, Pdk3 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA214692G3, Pdk3 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_145630
Synonyms	2610001M10Rik; AI035637
Summary	Inhibits pyruvate dehydrogenase activity by phosphorylation of the E1 subunit PDHA1, and thereby regulates glucose metabolism and aerobic respiration. Can also phosphorylate PDHA2. Decreases glucose utilization and increases fat metabolism in response to prolonged fasting, and as adaptation to a high-fat diet. Plays a role in glucose homeostasis and in maintaining normal blood glucose levels in function of nutrient levels and under starvation. Plays a role in the generation of reactive oxygen species (By similarity).[UniProtKB/Swiss-Prot Function]

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