Mouse Sik2 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Sik2
Locus ID	235344
Kit Components	GA214618G1, Sik2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA214618G2, Sik2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA214618G3, Sik2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_178710
Synonyms	G630080D20Rik; Snf1lk2
Summary	Phosphorylates 'Ser-789' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and inhibiting activity of TORCs, the CREB-specific coactivators, like CRTC2/TORC2 and CRTC3/TORC3 in response to cAMP signaling (PubMed:29211348).[UniProtKB/Swiss-Prot Function]

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