Mouse Pcid2 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Pcid2
Locus ID	234069
Kit Components	GA214504G1, Pcid2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA214504G2, Pcid2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA214504G3, Pcid2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_178708
Synonyms	A730042J05Rik
Summary	Required for B-cell survival through the regulation of the expression of cell-cycle checkpoint MAD2L1 protein during B cell differentiation (PubMed:20870947). As a component of the TREX-2 complex, involved in the export of mRNAs to the cytoplasm through the nuclear pores (By similarity). Binds and stabilizes BRCA2 and is thus involved in the control of R-loop-associated DNA damage and transcription-associated genomic instability. R-loop accumulation does not increase in PCID2-depleted cells (By similarity).[UniProtKB/Swiss-Prot Function]

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