Mouse Zc3hc1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Zc3hc1
Locus ID	232679
Kit Components	GA214371G1, Zc3hc1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA214371G2, Zc3hc1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA214371G3, Zc3hc1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001311086, NM_172735
Synonyms	1110054L24Rik; AU018540; AU019789; HSPC216; Nipa
Summary	Essential component of a SCF-type E3 ligase complex, SCF(NIPA), a complex that controls mitotic entry by mediating ubiquitination and subsequent degradation of cyclin B1 (CCNB1). Its cell-cycle-dependent phosphorylation regulates the assembly of the SCF(NIPA) complex, restricting CCNB1 ubiquitination activity to interphase. Its inactivation results in nuclear accumulation of CCNB1 in interphase and premature mitotic entry (By similarity). Overexpression may be able to protect from apoptosis induced by IL-3 withdrawal.[UniProtKB/Swiss-Prot Function]

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