Mouse Plekha8 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Plekha8
Locus ID	231999
Kit Components	GA214323G1, Plekha8 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA214323G2, Plekha8 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA214323G3, Plekha8 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001001335, NM_001164361
Synonyms	6330400G01; AA517676; BC052360; Fapp-2; Fapp2
Summary	Cargo transport protein that is required for apical transport from the trans-Golgi network (TGN). Transports AQP2 from the trans-Golgi network (TGN) to sites of AQP2 phosphorylation. Mediates the non-vesicular transport of glucosylceramide (GlcCer) from the trans-Golgi network (TGN) to the plasma membrane and plays a pivotal role in the synthesis of complex glycosphingolipids. Binding of both phosphatidylinositol 4-phosphate (PIP) and ARF1 are essential for the GlcCer transfer ability. Also required for primary cilium formation, possibly by being involved in the transport of raft lipids to the apical membrane, and for membrane tubulation (By similarity).[UniProtKB/Swiss-Prot Function]

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