Mouse Aimp2 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Aimp2
Locus ID	231872
Kit Components	GA214309G1, Aimp2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA214309G2, Aimp2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA214309G3, Aimp2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001172146, NM_146165
Synonyms	AA407136; AA407225; Aimp2(p38); Jtv1
Summary	Required for assembly and stability of the aminoacyl-tRNA synthase complex (PubMed:12060739). Mediates ubiquitination and degradation of FUBP1, a transcriptional activator of MYC, leading to MYC down-regulation which is required for aveolar type II cell differentiation (PubMed:12819782). Blocks MDM2-mediated ubiquitination and degradation of p53/TP53 (PubMed:18695251). Functions as a proapoptotic factor (PubMed:16135753).[UniProtKB/Swiss-Prot Function]

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