Mouse Smox activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Smox
Locus ID	228608
Kit Components	GA214017G1, Smox gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA214017G2, Smox gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA214017G3, Smox gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001177833, NM_001177834, NM_001177835, NM_001177836, NM_001177837, NM_001177838, NM_001177839, NM_001177840, NM_145533
Synonyms	B130066H01Rik; PAO; PAOh1; SMO
Summary	Flavoenzyme which catalyzes the oxidation of spermine to spermidine. Can also use N(1)-acetylspermine and spermidine as substrates, with different affinity depending on the isoform (isozyme) and on the experimental conditions. Plays an important role in the regulation of polyamine intracellular concentration and has the potential to act as a determinant of cellular sensitivity to the antitumor polyamine analogs. May contribute to beta-alanine production via aldehyde dehydrogenase conversion of 3-amino-propanal.[UniProtKB/Swiss-Prot Function]

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