Mouse Ano3 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Ano3
Locus ID	228432
Kit Components	GA214006G1, Ano3 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA214006G2, Ano3 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA214006G3, Ano3 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001081556, NM_001128103, NM_001355244, NM_001355245, NM_001355246
Synonyms	AI838058; B230324K02Rik; Tmem16c
Summary	Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylcholine and galactosylceramide (PubMed:23532839). Does not exhibit calcium-activated chloride channel (CaCC) activity (PubMed:23532839). Seems to act as potassium channel regulator and may inhibit pain signaling; can facilitate KCNT1/Slack channel activity by promoting its full single-channel conductance at very low sodium concentrations and by increasing its sodium sensitivity (PubMed:23872594).[UniProtKB/Swiss-Prot Function]

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