Mouse Arhgef4 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Arhgef4
Locus ID	226970
Kit Components	GA213900G1, Arhgef4 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA213900G2, Arhgef4 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA213900G3, Arhgef4 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_183019, NM_001368773
Synonyms	9330140K16Rik; Asef; ENSMUSG00000070955
Summary	Acts as guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Binding of APC may activate RAC1 GEF activity. The APC-ARHGEF4 complex seems to be involved in cell migration as well as in E-cadherin-mediated cell-cell adhesion (By similarity). Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression.[UniProtKB/Swiss-Prot Function]

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