Mouse Cdc42bpa activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Cdc42bpa
Locus ID	226751
Kit Components	GA213886G1, Cdc42bpa gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA213886G2, Cdc42bpa gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA213886G3, Cdc42bpa gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001033285, NM_001346804, NM_001346805, NM_001359541, NM_001359542, NM_001359543, NM_001359544, NM_001359545, NM_001359546, NM_001359547, NM_001359548, NM_001359549, NR_153194
Synonyms	A930014J19Rik; DMPK-like
Summary	Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2. In concert with MYO18A and LRP35A, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. Phosphorylates: PPP1R12A and LIMK2. May play a role in TFRC-mediated iron uptake (By similarity). In concert with FAM89B/LRAP25 mediates the targeting of LIMK1 to the lamellipodium resulting in its activation and subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation (PubMed:25107909).[UniProtKB/Swiss-Prot Function]

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