Mouse Zranb3 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Zranb3
Locus ID	226409
Kit Components	GA213852G1, Zranb3 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA213852G2, Zranb3 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA213852G3, Zranb3 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001285945, NM_027678, NM_172642, NM_001357573
Synonyms	4933425L19Rik; AH2; AI316834; C730006D09
Summary	DNA annealing helicase and endonuclease required to maintain genome stability at stalled or collapsed replication forks by facilitating fork restart and limiting inappropriate recombination that could occur during template switching events. Recruited to the sites of stalled DNA replication by polyubiquitinated PCNA and acts as a structure-specific endonuclease that cleaves the replication fork D-loop intermediate, generating an accessible 3'-OH group in the template of the leading strand, which is amenable to extension by DNA polymerase. In addition to endonuclease activity, also catalyzes the fork regression via annealing helicase activity in order to prevent disintegration of the replication fork and the formation of double-strand breaks (By similarity).[UniProtKB/Swiss-Prot Function]

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