Mouse Erlin1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Erlin1
Locus ID	226144
Kit Components	GA213830G1, Erlin1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA213830G2, Erlin1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA213830G3, Erlin1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001164359, NM_001164360, NM_145502
Synonyms	2810439N09Rik; C80197; Keo4; Spfh1
Summary	Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. Binds cholesterol and may promote ER retention of the SCAP-SREBF complex (By similarity).[UniProtKB/Swiss-Prot Function]

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