Mouse Kmt5b activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Kmt5b
Locus ID	225888
Kit Components	GA213803G1, Kmt5b gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA213803G2, Kmt5b gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA213803G3, Kmt5b gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001167884, NM_001167885, NM_001167886, NM_001167887, NM_001167888, NM_001167889, NM_144871
Synonyms	AA117471; C630029K18Rik; Suv4-20h1; Suv420h1
Summary	Histone methyltransferase that specifically trimethylates 'Lys-20' of histone H4. H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. KMT5B is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2). Plays a role in myogenesis by regulating the expression of target genes, such as EID3.[UniProtKB/Swiss-Prot Function]

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