Mouse Mapk4 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Mapk4
Locus ID	225724
Kit Components	GA213789G1, Mapk4 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA213789G2, Mapk4 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA213789G3, Mapk4 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_172632, NM_001360936
Synonyms	A330097D03Rik; Erk3; p63Mapk; Prkm4
Summary	Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK4/MAPK4 is phosphorylated at Ser-186 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK4/MAPK4. May promote entry in the cell cycle.[UniProtKB/Swiss-Prot Function]

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