Mouse Vps52 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Vps52
Locus ID	224705
Kit Components	GA213717G1, Vps52 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA213717G2, Vps52 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA213717G3, Vps52 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_172620, NM_001357329, NM_001357330
Synonyms	ARE1; D130068D18; D430041K17Rik; SAC2; Sacm2l; tclw5
Summary	Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD. Acts as component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized transferrin receptor (TFRC) to the plasma membrane.[UniProtKB/Swiss-Prot Function]

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