Mouse Setd4 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Setd4
Locus ID	224440
Kit Components	GA213692G1, Setd4 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA213692G2, Setd4 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA213692G3, Setd4 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_145482
Synonyms	AY037804; C21orf18; ORF21
Summary	Histone-lysine N-methyltransferase that acts as a regulator of cell proliferation, cell differentiation and inflammatory response (PubMed:31376731, PubMed:31794893, PubMed:33506343). Regulates the inflammatory response by mediating mono- and dimethylation of 'Lys-4' of histone H3 (H3K4me1 and H3K4me2, respectively), leading to activate the transcription of proinflammatory cytokines IL6 and TNF-alpha (PubMed:31376731). Also involved in the regulation of stem cell quiescence by catalyzing the trimethylation of 'Lys-20' of histone H4 (H4K20me3), thereby promoting heterochromatin formation (By similarity). Involved in proliferation, migration, paracrine and myogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) (PubMed:33506343).[UniProtKB/Swiss-Prot Function]

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