Mouse Rapgef3 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Rapgef3
Locus ID	223864
Kit Components	GA213650G1, Rapgef3 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA213650G2, Rapgef3 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA213650G3, Rapgef3 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001177810, NM_001177811, NM_144850, NM_001357630
Synonyms	2310016P22Rik; 9330170P05Rik; Epac; Epac1
Summary	Guanine nucleotide exchange factor (GEF) for RAP1A and RAP2A small GTPases that is activated by binding cAMP. Through simultaneous binding of PDE3B to RAPGEF3 and PIK3R6 is assembled in a signaling complex in which it activates the PI3K gamma complex and which is involved in angiogenesis. Plays a role in the modulation of the cAMP-induced dynamic control of endothelial barrier function through a pathway that is independent on Rho-mediated signaling. Required for the actin rearrangement at cell-cell junctions, such as stress fibers and junctional actin (By similarity).[UniProtKB/Swiss-Prot Function]

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