Mouse Wapl activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Wapl
Locus ID	218914
Kit Components	GA213574G1, Wapl gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA213574G2, Wapl gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA213574G3, Wapl gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001004436, NM_001301330
Synonyms	A530089A20Rik; BC037674; DIF-2; FOE; Wapal
Summary	Studies suggest that the protein encoded by this gene is important for the release of cohesin from chromatin. This gene product is thought to be essential for development, and reduced expression of this gene in cells causes defects in chromatin structure. High levels of expression of the human ortholog of this gene are observed in cervical cancers, and expression of the human ortholog of this gene in mice results in tumor formation. Alternative splicing results in multiple transcript variants encoding different protein isoforms. [provided by RefSeq, Aug 2014]

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