Mouse Cdc14b activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Cdc14b
Locus ID	218294
Kit Components	GA213538G1, Cdc14b gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA213538G2, Cdc14b gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA213538G3, Cdc14b gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001122989, NM_172587
Synonyms	2810432N10Rik; A530086E13Rik; AA472821; Cdc14B1; CDC14B3
Summary	Dual-specificity phosphatase involved in DNA damage response. Essential regulator of the G2 DNA damage checkpoint: following DNA damage, translocates to the nucleus and dephosphorylates FZR1/CDH1, a key activator of the anaphase promoting complex/cyclosome (APC/C). Dephosphorylates SIRT2 around early anaphase. Dephosphorylation of FZR1/CDH1 activates the APC/C, leading to the ubiquitination of PLK1, preventing entry into mitosis. Preferentially dephosphorylates proteins modified by proline-directed kinases (By similarity).[UniProtKB/Swiss-Prot Function]

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