Mouse Nrde2 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Nrde2
Locus ID	217827
Kit Components	GA213505G1, Nrde2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA213505G2, Nrde2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA213505G3, Nrde2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001290303, NM_183155
Synonyms	6720454P05Rik
Summary	Protein of the nuclear speckles that regulates RNA degradation and export from the nucleus through its interaction with MTREX an essential factor directing various RNAs to exosomal degradation. Changes the conformation of MTREX, precluding its association with the nuclear exosome and interaction with proteins required for its function in RNA exosomal degradation. Negatively regulates, for instance, the degradation of mRNAs and lncRNAs by inhibiting their MTREX-mediated recruitment to nuclear exosome. By preventing the degradation of RNAs in the nucleus, it promotes their export to the cytoplasm.[UniProtKB/Swiss-Prot Function]

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