Mouse Tmem106a activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Tmem106a
Locus ID	217203
Kit Components	GA213438G1, Tmem106a gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA213438G2, Tmem106a gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA213438G3, Tmem106a gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_144830, NM_001359325, NM_001359326, NM_001359327
Synonyms	0610008L10Rik; AI043106; BC022145
Summary	Activates macrophages and polarizes them into M1-like macrophages through the activation of the MAPK and NF-kappaB signaling pathway (PubMed:26215746). Upon activation, upregulates the expression of CD80, CD86, CD69 and MHC II on macrophages, and induces the release of pro-inflammatory cytokines such as TNF, IL1B, IL6, CCL2 and nitric oxide (PubMed:26215746). May play a role in inhibition of proliferation and migration (By similarity).[UniProtKB/Swiss-Prot Function]

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