Mouse Kat7 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Kat7
Locus ID	217127
Kit Components	GA213427G1, Kat7 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA213427G2, Kat7 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA213427G3, Kat7 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001195003, NM_001195004, NM_177619
Synonyms	Hbo1; Hboa; Myst2
Summary	Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Involved in H3K14 (histone H3 lysine 14) acetylation and cell proliferation (PubMed:23319590). Through chromatin acetylation it may regulate DNA replication and act as a coactivator of TP53-dependent transcription. Acts as a coactivator of the licensing factor CDT1. Specifically represses AR-mediated transcription.[UniProtKB/Swiss-Prot Function]

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