Mouse Fnip1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Fnip1
Locus ID	216742
Kit Components	GA213373G1, Fnip1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA213373G2, Fnip1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA213373G3, Fnip1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_173753
Synonyms	A730024A03Rik; AI838773; AW557298
Summary	Acts as a co-chaperone of HSP90AA1. Inhibits the ATPase activity of HSP90AA1 leading to reduction in its chaperone activity. Facilitates the binding of client protein FLCN to HSP90AA1. Competes with the activating co-chaperone AHSA1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins. May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. May regulate phosphorylation of RPS6KB1.[UniProtKB/Swiss-Prot Function]

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