Mouse Zfp598 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Zfp598
Locus ID	213753
Kit Components	GA213174G1, Zfp598 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA213174G2, Zfp598 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA213174G3, Zfp598 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_183149, NM_001348231
Synonyms	BC023040; Ntrap; Znf598
Summary	E3 ubiquitin-protein ligase that plays a key role in the ribosome quality control (RQC), a pathway that takes place when a ribosome has stalled during translation. Required for ribosomes to terminally stall during translation of poly(A) sequences by mediating monoubiquitination of 40S ribosomal protein RPS10/eS10, RPS20/uS10 and RPS3/uS3. Stalling precludes synthesis of a long poly-lysine tail and initiates the RQC pathway to degrade the potentially detrimental aberrant nascent polypeptide. Also acts as a component of the 4EHP-GYF2 complex, a multiprotein complex that acts as a repressor of translation initiation.[UniProtKB/Swiss-Prot Function]

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