Mouse Plekhg6 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Plekhg6
Locus ID	213522
Kit Components	GA213161G1, Plekhg6 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA213161G2, Plekhg6 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA213161G3, Plekhg6 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_198604
Synonyms	BC026778; Gm155
Summary	Guanine nucleotide exchange factor activating the small GTPase RHOA, which, in turn, induces myosin filament formation. Also activates RHOG. Does not activate RAC1, or to a much lower extent than RHOA and RHOG. Part of a functional unit, involving PLEKHG6, MYH10 and RHOA, at the cleavage furrow to advance furrow ingression during cytokinesis. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with EZR, required for normal macropinocytosis (By similarity).[UniProtKB/Swiss-Prot Function]

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