Mouse Tnpo2 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Tnpo2
Locus ID	212999
Kit Components	GA213118G1, Tnpo2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA213118G2, Tnpo2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA213118G3, Tnpo2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001122843, NM_145390, NM_001364031, NM_001364032, NM_001364033, NM_001364034
Synonyms	1110034O24Rik; AA414969; AI464345; AI852433; IPO3; Knpb2b; Kpnb2b; TRN2
Summary	Probably functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity).[UniProtKB/Swiss-Prot Function]

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