Mouse Unc5d activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Unc5d
Locus ID	210801
Kit Components	GA212997G1, Unc5d gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA212997G2, Unc5d gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA212997G3, Unc5d gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001347498, NM_001347499, NM_001347500, NM_001347501, NM_153135
Synonyms	D930029E11Rik; mKIAA1777; Unc5h4
Summary	Receptor for the netrin NTN4 that promotes neuronal cell survival (PubMed:21216843). Plays a role in cell-cell adhesion and cell guidance. Receptor for netrin involved in cell migration (By similarity). Plays a role in the regulation of neuronal cell migration in the developing brain via its interaction with FLRT2 (PubMed:21673655). Plays a role in axon guidance by mediating axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding (PubMed:21673655). May play a role in apoptosis in response to DNA damage. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (By similarity). Mediates cell-cell adhesion via its interaction with FLRT3 on an adjacent cell (PubMed:26235030).[UniProtKB/Swiss-Prot Function]

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