Mouse Wdr11 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Wdr11
Locus ID	207425
Kit Components	GA212812G1, Wdr11 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA212812G2, Wdr11 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA212812G3, Wdr11 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_172255
Synonyms	2900055P10Rik; AW489876; Brwd2; mKIAA1351
Summary	Involved in the Hedgehog (Hh) signaling pathway, is essential for normal ciliogenesis (PubMed:29263200). Regulates the proteolytic processing of GLI3 and cooperates with the transcription factor EMX1 in the induction of downstream Hh pathway gene expression and gonadotropin-releasing hormone production (PubMed:29263200). WDR11 complex facilitates the tethering of Adaptor protein-1 complex (AP-1)-derived vesicles. WDR11 complex acts together with TBC1D23 to facilitate the golgin-mediated capture of vesicles generated using AP-1 (By similarity).[UniProtKB/Swiss-Prot Function]

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