Mouse Stxbp5l activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Stxbp5l
Locus ID	207227
Kit Components	GA212804G1, Stxbp5l gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA212804G2, Stxbp5l gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA212804G3, Stxbp5l gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001114611, NM_001114612, NM_001114613, NM_172440
Synonyms	9430094L02; A830015P08Rik; LLGL4; T2dm1; t2md1; tomosyn-2
Summary	Plays a role in vesicle trafficking and exocytosis inhibition (PubMed:25002582). In pancreatic beta-cells, inhibits insulin secretion probably by interacting with and regulating STX1A and STX4, key t-SNARE proteins involved in the fusion of insulin granules to the plasma membrane (PubMed:21998599). Plays also a role in neurotransmitter release by inhibiting basal acetylcholine release from axon terminals and by preventing synaptic fatigue upon repetitive stimulation (PubMed:24744148). Promotes as well axonal outgrowth (By similarity).[UniProtKB/Swiss-Prot Function]

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